Crocin (CR), an important carotenoid in saffron, is known for its significant biological benefits. Despite its therapeutic potential, there are some challenges that hamper its use as an effective functional agent. These include limited absorption, low bioavailability, and inadequate stability. Nanodelivery systems are useful in addressing these obstacles and enhancing CR effectiveness through various mechanisms. This review aims to provide a recent overview of the research advancements in CR-loaded nanocarriers and to explore their potential benefits in food and pharma applications. Various research studies have been conducted on different nanocarriers for the delivery of CR, and their findings suggest that optimal encapsulation can improve the stability of CR, thereby preserving its therapeutic potency. Hence, nanocarriers show great promise as a means to develop nutraceuticals with enhanced bioavailability and efficacy.